Protein Domain : Macrophage stimulating protein IPR043575

Type	Family
Description	Macrophage stimulating protein (MSP; also known as hepatocyte growth factor-like protein) and its close relative hepatocyte growth factor ( ) are non-peptidase homologues belonging to MEROPS peptidase family S1 (chymotrypsin family, clan PA(S)), subfamily S1A. MSP is a plasma protein that is secreted from the liver into the circulation as a single-chain, biologically inactive pro-protein. Proteolytic cleavage at a single site yields the active molecule composed of disulphide-linked alpha and beta chains. The MSP receptor is a transmembrane tyrosine kinase found in murine resident peritoneal macrophages but not exudate macrophages or blood monocytes. MSP induces phosphorylation of the receptor cytoplasmic domain, association of phosphatidylinositol (PI)-3 kinase with the receptor, and phosphorylation of receptor-bound PI-3 kinase. MSP may function in tissue injury or wound healing [ ].
Short Name	MSP_HGFL