Protein Domain : MAPK-interacting and spindle-stabilising protein IPR031653

Type  Family
Description  MAPK-interacting and spindle-stabilising protein (MISS) is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localisation signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII (meiosis metaphase II) spindle. MISS is the first example of a physiological MAPK-substrate that is stabilised in MII that specifically regulates MII spindle integrity during the cytostatic factor (CSF) arrest [ ].
Short Name  MISS

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