Protein Domain : DAPIN domain IPR004020

Type	Domain
Description	The DAPIN (Domain in Apoptosis and INterferon response) domain is an 80-100- residue domain which is found in the N terminus of diverse vertebrate andvertebrate-specific viral proteins involved in apoptosis, cancer, inflammation, and immune response. The DAPIN domain can be found alone or inassociation with other domains [ , , ] like CARD, LRR, SPRY, Caspase or Zinc finger B-box. It has been proposed that the DAPIN domain might have an adaptor function, coupling apoptosis and immune disorders [, , ]. It has been shown that the DAPIN domain is a protein-protein interaction domain capable of binding to other DAPIN domains [].Secondary structure predictions have identified the DAPIN domain as mostly α-helical and it has been suggested that it could belong to the DEATH-domain-fold superfamily, which includes the CARD, the DEATH domain (DD) and the DEATH effector domain (DED) [ , , ].The DAPIN domain has also been called pyrin domain, pyrin N-terminal homology domain (PYD) or PAAD (after the protein families pyrin, AIM, ASC death-domain-like) [ , ].
Short Name	DAPIN