Protein Domain : Non-structural protein 6, coronavirus IPR043610

Type	Domain
Description	This entry represents the Non-structural Protein 6 (NSP6) found in coronaviruses. Coronaviruses encode large replicase polyproteins which are proteolytically processed by viral proteases to generate mature Nonstructural Proteins (NSPs) [ ]. NSP6 is a membrane protein containing 6 transmembrane domains with a large C-terminal tail []. NSP6 from the avian coronavirus, infectious bronchitis virus (IBV) and the mouse hepatitis virus (MHV) have been shown to localise to the ER and to generate autophagosomes []. Coronavirus NSP6 proteins have also been shown to limit autophagosome expansion. This may favour coronavirus infection by reducing the ability of autophagosomes to deliver viral components to lysosomes for degradation []. NSP6 from IBV, MHV and severe acute respiratory syndrome coronavirus (SARS-CoV) have also been found to activate autophagy [, ].
Short Name	NSP6_CoV