Protein Domain : Transcriptional enhancer factor, metazoa IPR016361

Type	Family
Description	Proteins in the transcriptional enhancer factor family (also known as TEAD family, includes TEAD 1 to 4) play a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumour suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. TEAD transcription factors act by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction [ , ]. This entry includes protein Scalloped from Drosophila melanogasterwhich in combination with protein Vestigial promotes wing formation [ ], and in combination with Yorkie which promotes transcriptional activity and movement of Yorkie to the nucleus [].
Short Name	TEF_metazoa