Protein Domain : Major outer membrane lipoprotein Lpp IPR016367

Type  Family
Description  This entry represents the Major outer membrane lipoprotein (Lpp, also known as murein lipoprotein), which controls the distance between the inner and outer membranes [ , ]. This abundant protein contains lipids in its N-terminal which anchor it to the outer membrane. This is the only protein known to bind covalently to the peptidoglycan network (PGN) but it also binds it through non-covalent interactions. About one-third of the Lpp is bound to the cell wall and the rest is free in the periplasm. Lpp have a structural function mediating the interactions between the outer membrane and PGN to assure the correct distance between them and contributes to the structural and functional integrity of the cell membrane [ ]. The role of the periplasm free Lpp remains unknown.
Short Name  MOM_Lpp

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