Protein Domain : Siroheme biosynthesis protein Met8 IPR028161

Type	Family
Description	In Saccharomyces cerevisiae, Met8 is a bifunctional dehydrogenase ( ) and ferrochelatase ( ) [ ]. It catalyses the final two steps in the biosynthesis of sirohaem, involving a NAD(+)-dependent dehydrogenation of precorrin-2 to generate sirohydrochlorin followed by ferrochelation to yield sirohaem []. Siroheme is a heme-like prosthetic group used by sulfite and nitrite reductases []. The structure of Met8 has been resolved. A single active site, Asp141, has been shown to play an essential role in both dehydrogenase and chelatase processes []. This entry also includes precorrin-2 dehydrogenase (also known as siroheme synthase) from bacteria which catalyzes the dehydrogenation of precorrin-2 to form sirohydrochlorin, a precursor in siroheme biosynthesis and in anaerobic adenosylcobalamin biosynthesis [ ].
Short Name	Met8