Protein Domain : Effector protein NleD-like IPR028208

Type	Family
Description	This entry represents Escherichia coli effector protein NleD-like proteins. Enteropathogenic E. coli infection can trigger an inflammatory response in host cells. This inflammatory response can then be inhibited by injecting several effectors that block the NF-kappa B pathway to the host cells. One of these effectors from E. coli, NleD, cleaves and inactivates c-Jun N-terminal kinase (JNK), which is a serine/threonine kinase that affects the regulation of cellular proliferation, apoptosis, inflammation, and tumorigenesis [ ]. NleD contains an HEXXH motif, typical of zinc metallopeptidases [].
Short Name	Effector_pro_NleD-like