Protein Domain : Proliferation-associated protein 2G4/ARX1 IPR047113

Type	Family
Description	This family includes proliferation-associated protein 2G4 (PA2G4, also known as ErbB3-binding protein 1) and its homologues such as ARX1 from yeast [ , ]. PA2G4 is a RNA-binding protein involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing [, ]. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals []. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases [, ]. ARX1 from yeast is involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit []. Although these proteins belong to the peptidase M24 family, they do not contain metal cofactors and lack aminopeptidase activity.
Short Name	PA2G4/ARX1