Protein Domain : Meiosis-specific protein Hop1 IPR016573

Type	Family
Description	Hop1 is a key structural component of Saccharomyces cerevisiae synaptonemal complex, a complex found at synapses between homologous chromosomes during meiosis, and form when sister chromatids condense upon axial elements [ , ]. Hop1 is involved in both gene conversion and crossing over between homologues, as well as enforces meiotic recombination checkpoint control over the progression of recombination intermediates. It interacts with the Holliday junction, changes its global conformation and blocks the dissolution of the junction by a RecQ helicase in vitro []. Red1, Hop1 and Mek1 are three yeast meiosis-specific chromosomal proteins that uphold the interhomologue (IH) bias of meiotic recombination [ ]. It has been suggested that Hop1 and Mek1 promote interactions between homologous chromosomes rather than inhibiting interactions between sister chromatids []. The localisation of Hop1 and Mek1 to axial elements is dependent on Red1 []. Hop1 contains an intrinsically disordered N-terminal domain and a protease-resistant C-terminal domain. The N-terminal domain is necessary for spore formation, while the C-terminal domain exhibits strong homotypic as well as heterotypic protein-protein interactions [ ].
Short Name	Hop1