Protein Domain : Arsenical-resistance protein Acr3 IPR004706

Type	Family
Description	Members of the ACR3 family of arsenite (As(III)) permeases confer resistance to arsenic by extrusion from cells [ ]. They exist in prokaryotes and eukaryotes (lower plants and fungi) [, ]. The ACR3 permeases have ten-transmembrane span topology []. Corynebacterium glutamicum has three Acr3 proteins, CgAcr3-1, CgAcr3-2, and CgAcr3-3. CgAcr3-1 is thought to be an antiporter that catalyses arsenite-proton exchange [].The Shewanella oneidensis Acr3 is not able to transport As(III) and confers resistance only to arsenate (As(V)) [ ], whereas the Acr3 orthologue from Synechocystis mediates tolerance to As(III), As(V) and antimonite (Sb(III)) [].In budding yeast, overexpression of the Acr3 gene confers an arsenite- but not an arsenate-resistance phenotype [ ]. Saccharomyces cerevisiae Acr3 is a plasma membrane metalloid/H+ antiporter that transports arsenite and antimonite [].
Short Name	Arsenical-R_Acr3