Protein Domain : Nuclear factor interleukin-3-regulated protein IPR016743

Type	Family
Description	Nuclear factor interleukin-3-regulated protein (NFIL3, also known as E4BP4) was first identified as a transcriptional repressor capable of binding an activating transcription factor (ATF) DNA consensus sequence site in the adenovirus E4 promoter [ ]. Later, it was independently identified as a transactivator of the IL3 promoter in human T cells [].E4BP4 is involved in a several biological processes, including transcriptional control of the circadian clock, neuron growth and survival, osteoblast function, and regulation of ovulation [ ]. It is essential for the development of NK cells and CD8alpha(+) conventional dendritic cells, and is also involved in macrophage activation, polarisation of CD4(+) T cell responses and B cell class switching to IgE [].
Short Name	NFIL3/E4BP4