Protein Domain : RBM6, OCRE domain IPR035617

Type	Domain
Description	RNA-binding protein 6 (RBM6) contains two RNA-binding motifs and shares protein sequence similarity with RBM5 [ ]. RBM6 is targeted to the splicing speckles and nascent transcripts []. It may act mainly as a splicing activator []. The elevated expression of RBM6 has been linked to certain tumours []. A RBM6-CSF1R fusion has been found in acute megakaryoblastic leukemia [].RBM6 contains two RNA recognition motifs (RRMs), an OCtamer REpeat (OCRE) domain, two C2H2-type zinc fingers, a nuclear localization signal, and a G-patch/D111 domain. In contrast to RBM5, RBM6 has an additional unique domain, the POZ (poxvirus and zinc finger) domain, which may be involved in protein-protein interactions and inhibit binding of target sequences by zinc fingers. This entry represents the OCRE domain.The OCRE (OCtamer REpeat) domain contains five repeats of an 8-residue motif, which were shown to form β-strands. Based on the architectures of proteins containing OCRE domains, a role in RNA metabolism and/or signalling has been proposed [ ].
Short Name	RBM6_OCRE