Protein Domain : Adrenocortical dysplasia protein IPR028631

Type	Family
Description	Adrenocortical dysplasia protein (acd, also known as TPP1) is a component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways [ ]. It also forms a heterodimer with POT1 that increases the activity and processivity of the telomerase core enzyme [].This entry also includes fission yeast TPP1 homologue, Tpz1. Together with Pot1 it forms a complex that protects telomeres and regulates telomere length [ ].
Short Name	ACD