Protein Domain : Mitochondrial carrier protein Mtm1-like IPR045315

Type  Family
Description  This entry represents a group of mitochondrial carrier proteins, including Mtm1 from budding yeasts and SLC25A39/40 from humans. Mtm1 is a pyridoxal 5'-phosphate (PLP) transporter and is involved in mitochondrial iron homeostasis []. SLC25A39 and its paralogue SLC25A40 are mitochondrial transporters essential for glutathione import into mitochondria, which is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis []. Knockdown of SLC25A39 in a zebrafish model has been shown to disrupt heme biosynthesis and results in profound anemia [].
Short Name  Mtm1-like

0 Child Features

0 Gene Families

0 Genes

1 Ontology Annotations

1 Parent Features

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