Protein Domain : Antitoxin CbeA superfamily IPR038025

Type	Homologous_superfamily
Description	This is a superfamily of cognate antitoxins to the CbtA toxins that act by inhibiting the polymerisation of cytoskeletal proteins (see ). These are classified as a type IV toxin-antitoxin system [ ]. The superfamily includes three proteins from E. coli YagB, YeeU and YfjZ, which act not by forming a complex with CbtA but through acting as antagonists to the CbtA toxicity, by stabilising the CbtA target proteins. For example, YeeU binds directly to both MreB and FtsZ and enhances the bundling of their filaments in vitro. YeeU is also able to neutralise the toxicity caused by other MreB and FtsZ inhibitors, such as A22 [S-(3, 4-dichlorobenzyl)isothiourea]for MreB, and SulA and DicB for FtsZ [ ]. Thus CbeA, for cytoskeleton bundling-enhancing factor A, is proposed as a general name for all of these antitoxin proteins.The molecular structure has a beta(2)-α-β(3) fold arranged in two layers (alpha/beta).
Short Name	CbeA_sf