Protein Domain : Nonstructural protein NS-S, bunyaviral IPR004915

Type	Family
Description	Bunyavirus has three genomic segments: small (S), middle-sized (M), and large (L). The S segment encodes the nucleocapsid and a non-structural protein (NSs). The M segment codes for two glycoproteins, G1 and G2, and another non-structural protein (NSm). The L segment codes for an RNA polymerase.This entry represents the segment S non-structural protein, NSs. This protein is present in infected cells, but absent from purified virus particles [ , ]. It is not essential for virus replication, but contributes substantially to pathogenesis []. This may be due to the capacity of NSs to interfere with the host immune response; it has been shown to inhibit the production of alpha/beta interferons, and to inhibit interferon regulatory factor-mediated cell death [, ]. Studies indicate that NSs suppresses host mRNA synthesis by sequestering subunits of the basal transcription factor TFIIH, explaining the dramatic drop in RNA synthesis observed upon infection [].
Short Name	NS-S_bunyaviral