Protein Domain : Zorya protein ZorC, EH signature domain IPR028943

Type	Domain
Description	This domain is found in Zorya protein ZorC, a component of antiviral defense system Zorya type I, which confers resistance to phage infection. The function of ZorC is not clear but it may be involved in the sensing and inactivation of phage DNA, and if phage inactivation fails, the ZorAB proton channel opens up, leading to membrane depolarization and cell death [ ]. This domain was described as EH_signature as it contains a strongly conserved glutamate at the N terminus and a histidine at the C terminus [], first described in a SWI2/SNF2 four gene operon []. Its strict-neighbourhood association with SWI2/SNF2 ATPase strongly suggests a function in conjunction with it []. The other genes in the operon are a OmpA protein and a TM protein []. This has a DNA related function along with the TerY-P triad [].
Short Name	ZorC_EH_Signature_dom