Protein Domain : P450-derived glycosyltranferase activator IPR030958

Type	Family
Description	Members of this family resemble cytochrome P450 by homology, but lack a critical heme-binding Cys residue. Members in general are encoded next to a glycosyltransferase gene in a natural products biosynthesis cluster, physically interact with it, and help the glycosyltransferase achieve high specificity while retaining high activity. Many members of this family assist in the attachment of a sugar moiety to a natural product such as a polyketide [ ]. This entry includes Streptomyces venezuelae DesVII and its homologues, such as OleP1 from the oleandomycin-producingStreptomyces antibioticus, DnrQ from the doxorubicin-producing Streptomyces peucetius, and TylMIII from the tylosin-producing Streptomyces fradiae [ ]. DesVII is a glycosyltransferase involved in the biosynthesis of the macrolide antibiotics methymycin, neomethymycin, narbomycin, and pikromycin in Streptomyces venezuelae. It requires an auxiliary activator protein DesVIII for full activity. DesVII/DesVIII catalyses the attachment of TDP-desosamine to 10-deoxymethynolide or narbonolide [ ].
Short Name	P450-rel_GT_act