Protein Domain : Mastadenovirus E4/Orf3 superfamily IPR038368

Type	Homologous_superfamily
Description	This superfamily consists of several Mastadenovirus E4 ORF3 proteins. Early proteins E4 ORF3 and E4 ORF6 have complementary functions during viral infection. Both proteins facilitate efficient viral DNA replication, late protein expression, and prevention of concatenation of viral genomes. A unique function of E4 ORF3 is the reorganisation of nuclear structures known as PML oncogenic domains (PODs). This domain is annotated as pleiotropic. It is relevant to highlight that early proteins E4 ORF3 and E4 ORF6 have complementary functions during viral infection which include efficient viral DNA replication, late protein expression, and prevention of concatenation of viral genomes. However, characterisation of E4 ORF3 has revealed several unique functions such as the reorganisation of nuclear structures known as PML oncogenic domains (PODs), which are nuclear structures whose function still remains unclear although these have been implicated in several critical cellular processes such as, regulation of transcription, apoptosis, transformation, and response to interferon [ ].
Short Name	Mastadenovirus_E4/Orf3_sf