Protein Domain : EF-G binding protein, N-terminal domain superfamily IPR038344

Type	Homologous_superfamily
Description	This superfamily represents a domain found in the N terminus of the FusB ( ), FusC ( ), and FusD ( ) proteins from Staphylococcus aureus. They are elongation factor G (EF-G) binding proteins that are linked to the fusidic acid (FA) resistance in S. aureus [ , ]. The FusB proteins are two-domain metalloproteins, and this N-terminal domain forms a four-helical bundle whose helices help to stabilise the conformation of the treble-clef zinc-finger in the C-terminal domain [ ]. FA is an antibiotic that binds to EF-G, preventing its release from the ribosome, thus stalling bacterial protein synthesis. The FusB proteins provide FA resistance by preventing formation or facilitating dissociation of the FA-locked EF-G-ribosome complex during elongation and ribosome recycling [].
Short Name	EF-G_N_sf