Protein Domain : Centromere protein W IPR028847

Type	Family
Description	Centromere protein W (CENP-W) is a component of the CENPA-NAC (nucleosome-associated) complex, which plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation [ ]. CENP-W gene is up-regulated in various types of cancers and was first identified as a putative oncogene, CUG2 []. It can be regulated by CSN5, a component of the CSN complex involved in protein degradation via the ubiquitin-proteasome pathway []. The DNA-binding regions in CENP-T or CENP-W is essential for inducing positive supercoils into DNA and for the kinetochore targeting of the CENP-T-W-S-X complex [].
Short Name	CENP-W