Protein Domain : Probable serine/threonine-protein kinase GDT family IPR026237

Type	Family
Description	The life-cycle of Dictyostelium consists of two distinct phases: growth and development [ ]. The control of the growth-differentiation transition (GDT) is not fully understood, and only a handful of genes involved in the process have been elucidated. Amongst these is a family containing at least 9 closely related genes, of which gdt1 and gdt2 were the first members to be identified [, ]. It is thought that the different family members may control similar cellular processes, but respond to different environmental cues [].The gdt1 and gdt2 gene products, GDT1 and GDT2, are similar in many ways, but there are important differences. GDT1 is a 175kDa protein with 4 putative transmembrane (TM) domains [ ]. The C-terminal amino acid sequence shares some similarity with the catalytic domain of protein kinases; while this domain is well conserved in GDT2, it is thought to be non-functional in GDT1 []. Similar observations have been made for other family members: hence, for example, GDT3 and GDT4 encode complete well conserved kinase domains, and are therefore probably functional []; conversely, GDT6 and GDT8 appear to encode proteins with degenerate protein kinase domains; and the C-terminal sequence of GDT5 seems unrelated to protein kinases, while GDT7 appears to be truncated, and stops before the protein kinase domain.
Short Name	STKINASEGDT