Protein Domain : Jagged/Serrate protein IPR026219

Type	Family
Description	The Notch signalling pathway is a conserved intercellular signalling mechanism that is essential for proper embryonic development in numerous metazoan organisms [ ]. Members of the Notch gene family encode transmembrane (TM) receptors that are critical for various cell-fate decisions. Multiple ligands that activate Notch and related receptors have been identified, including the Delta and Serrate proteins in Drosophila, and Jagged, the vertebrate orthologue of Serrate [].Members of the Jagged/Serrate group are single-pass TM proteins. They possess a large extracellular region that contains a highly conserved disulphide-rich Delta/Serrate/LAG-2 (DSL) domain, and a variable number of EGF repeats. The cytoplasmic tail region is relatively short (100-150 amino acids) and, following proteolytic cleavage, may translocate to the nucleus to mediate nuclear signalling events [ ].Defects in Jagged have been shown to result in Alagille syndrome, an autosomal dominant disorder that results in a paucity of intrahepatic bile ducts [ ].This entry represents the Jagged/Serrate protein family.
Short Name	Jagged/Serrate