Protein Domain : Type IV secretion system protein VirB8/PtlE IPR026264

Type	Family
Description	Bacterial type IV secretion systems mediate the transfer of macromolecular substrates into various target cells, including the transfer of virulence proteins into eukaryotic host cells. The virB operon constitutes a major determinant of virulence [ ]. It mediates invasion, proinflammatory activation and antiapoptotic protection of endothelial cells. VirB-dependent changes of human endothelial cell (HEC) function include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-kappa-B, inhibition of early and late events of apoptosis, leading to an increased cell survival, and, at high infection doses, a cytostatic or cytotoxic effect, which interferes with a potent VirB-independent mitogenic activity [, ]. Protein PtlE is a component of the type IV secretion system ptl required for secretion of assembled pertussis toxin (a toxin from Bordetella pertussis) through the outer membrane [ , , ]. PtlE has peptidoglycanase activity and is responsible for the local removal or rearrangement of the peptidoglycan layer during the assembly of the Ptl secretion complex [].
Short Name	VirB8/PtlE