Protein Domain : Multi antimicrobial extrusion protein DinF-like IPR044644

Type	Family
Description	Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts [ ]. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA []. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds [].This entry also includes DETOXIFICATION 42-47 (DTX42-47) from Arabidopsis. DTX42 (also known as AtMATE) is a citrate transporter critical for aluminum tolerance [ ]. DTX43 is a citrate transporter responsible for loading citrate into xylem tissues, which helps facilitate iron transport to shoots [, ].In general, proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR) [ , ]. These proteins mediate resistance to a wide range of cationic dyes, fluroquinolones, aminoglycosides and other structurally diverse antibodies and drugs. MATE proteins are found in bacteria, archaea and eukaryotes. These proteins are predicted to have 12 α-helical transmembrane regions, some of the animal proteins may have an additional C-terminal helix [].
Short Name	DinF-like