Protein Domain : Bacterial extracellular solute-binding protein IPR006059

Type	Family
Description	Bacterial high affinity transport systems are involved in active transport of solutes across the cytoplasmic membrane. Most of the bacterial ABC (ATP-binding cassette) importers are composed of one or two transmembrane permease proteins, one or two nucleotide-binding proteins and a highly specific periplasmic solute-binding protein. In Gram-negative bacteria the solute-binding proteins are dissolved in the periplasm, while in archaea and Gram-positive bacteria, their solute-binding proteins are membrane-anchored lipoproteins [ , ]. On the basis of sequence similarities, the vast majority of these solute-binding proteins can be grouped into eight family clusters [ ], which generally correlate with the nature of the solute bound. This entry represents the family 1. Family 1 members include:Maltose/maltodextrin-binding proteins of Enterobacteriaceae (gene malE) [ ] and Streptococcus pneumoniae malXMultiple oligosaccharide binding protein of Streptococcus mutans (gene msmE)Escherichia coli glycerol-3-phosphate-binding proteinSerratia marcescens iron-binding protein (gene sfuA) and the homologous proteins (gene fbp) from Haemophilus influenzae and NeisseriaE. coli thiamine-binding protein (gene tbpA) Interestingly, these thiamin-binding proteins share protein structural similarity with thiaminase-I. They may be evolved from a common ancestor [ ]. This entry also includes thiaminase-1 from Paenibacillus thiaminolyticus (Bacillus thiaminolyticus).
Short Name	SBP