Protein Domain : Fimbrial isopeptide formation D2 domain IPR026466

Type	Domain
Description	The Streptococcus Pneumoniae pilus backbone protein, RrgB, has three tandem domains with Lys-to-Asn isopeptide bonds, but these three regions are extremely divergent in sequence. This entry represents the D2 domain [ ]. It occurs just once in many surface proteins but up to twenty times in some pilin subunit proteins. Three of every four members have the typical Gram-positive C-terminal motif, LPXTG, although in many cases this motif may be involved in pilin subunit cross-linking rather than cell wall attachment. Proteins with this domain include fimbrial proteins with lectin-like adhesion functions, and the majority of characterised members are involved in surface adhesion to host structures [, ].
Short Name	Fim_isopep_form_D2_dom