Protein Domain : Effector protein NleG superfamily IPR038436

Type	Homologous_superfamily
Description	Many bacterial pathogens deliver effector proteins into host cells via a type III secretion system. These effector proteins then alter the host cell's biology in ways that are advantageous to the pathogen. The NleG protein and its homologues form the largest family of effector proteins in the enterohemorrhagic Escherichia coli O157:H7, with 14 members identified in the Sakai strain alone [ ]. NleG family members share a conserved C-terminal domain that forms a structure similar to the RING finger/U-box domain found in eukaryotic ubiquitin ligases []. They selectively interact with human E2 ubiquitin conjugating enzymes and exhibit in vitro activity typical of eukaryotic E3 ligases, though the role of this activity in pathogenesis is not yet known.
Short Name	Effector_NleG_sf