Protein Domain : Velvet domain superfamily IPR038491

Type	Homologous_superfamily
Description	The fungus-specific velvet family of regulatory proteins plays a key role in coordinating secondary metabolism and differentiation processes such asasexual or sexual sporulation and sclerotia or fruiting body formation. These velvet regulators are present in most parts of the fungal kingdom fromchytrids to basidiomycetes. Velvet proteins interact with each other, alone ("homodimers"), in various combinations ("heterodimers"), and also with other proteins. The velvet proteins share a homologous region comprising about 150amino acids, which lack significant sequence similarity to any other known proteins. The velvet domain is involved in specific DNA binding as well as inthe dimerization of the different velvet proteins, resulting in the formation of homo- and heterodimers [, ].The velvet domain is an RHD-like domain related to NF-kappaB. It folds into a highly twisted β-sandwich composed of seven antiparallel β-strands. One side of the β-sandwich isinvolved in dimer formation, whereas the other one is flanked by several loops of which two fold into an α-helix. These α-helical fragments arelocated between β-strands 2 and 3 and at the C terminus [ , ].
Short Name	Velvet_dom_sf