Protein Domain : Uncharacterised protein family UPF0201 IPR002739

Type	Family
Description	This entry represents a family of archaeal proteins, including UPF0201 protein PH1010 from Pyrococcus horikoshii ( ), which is composed of five α-helices (1-5) and eight β-strands (1-8) with the following topology: β-1, α-1, β-2, β-3, α-2, α-3, β-4, β-5, α-4, β-6, α-5, β-7, β-8. The first six β-strands (1-6) form a slightly twisted antiparallel β-sheet and face five α-helices on one side. The last two β-strands form an antiparallel β-sheet in the C terminus. PH1010 forms a characteristic homodimer structure in the crystal. Dimerisation of the molecule is crucial for function. The structure resembles that of some ribosomal proteins such as the 50S ribosomal protein L5 [ ]. Although the structure resembles that of the RRM-type RNA-binding domain of the ribosomal L5 protein, the residues involved in RNA-binding in the L5 protein are not conserved in this family []. Despite this, RNA-binding protein PAB1135 from Pyrococcus abyssi (), which belongs to this family, bind to double-stranded RNA in a non-sequence specific manner [ ].
Short Name	UPF0201