Protein Domain : GINS complex protein Sld5, alpha-helical domain IPR038749

Type	Domain
Description	Sld5 is a component of GINS tetrameric protein complex, and within the complex Sld5 interacts with Psf1 via its N-terminal A-domain, and with Psf2 through a combination of the A and B domains [ , ]. Sld5 in Drosophila is required for normal cell cycle progression and the maintenance of genomic integrity []. GINS is a complex of four subunits (Sld5, Psf1, Psf2 and Psf3) that is involved in both initiation and elongation stages of eukaryotic chromosome replication []. Besides being essential for the maintenance of genomic integrity, GINS plays a central role in coordinating DNA replication with cell cycle checkpoints and is involved in cell growth. The eukaryotic GINS subunits are homologous and homologues are also found in the archaea; the complex is not found in bacteria. The four subunits of the complex consist of two domains each, termed the α-helical (A) and β-strand (B) domains. The A and B domains of Sld5/Psf1 are permuted with respect to Psf1/Psf3 [, , , , , , ].
Short Name	Sld5_GINS_A