Protein Domain : Adaptor protein Cbl IPR024162

Type  Family
Description  Cbl (Casitas B-lineage lymphoma) is an adaptor protein that functions as a negative regulator of many signalling pathways that start from receptors at the cell surface, including tyrosine kinases, cytokine receptors, and T-cell or B-cell receptors. There are three Cbl related proteins known to date: Cbl, CblB, and CblC/Cbl3 [ ]. Cbls function as ubiquitin E3 ligase proteins, accepting ubiquitin from specific E2 ubiquitin-conjugating enzymes and transferring it to substrates, promoting their degradation [ ] or endocytosis [].
Short Name  Adaptor_Cbl

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2 Ontology Annotations

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