Protein Domain : D,D-heptose 7-phosphate kinase IPR014606

Type	Family
Description	This group of enzymes belongs to the GHMP kinase domain superfamily. GHMP kinases are a unique class of ATP-dependent enzymes (the abbreviation of which refers to the original members: galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase) [ ]. Enzymes belonging to this superfamily contain three well-conserved motifs, the second of which has the typical sequence Pro-X-X-X-Gly-Leu-X-Ser-Ser-Ala and is involved in ATP binding []. The phosphate binding loop in GHMP kinases is distinct from the classical P-loops found in many ATP/GTP binding proteins. The bound ADP molecule adopts a rare syn conformation and is in the opposite orientation from those bound to the P-loop-containing proteins []. GHMP kinases display a distinctly bilobal appearance with their N-terminal subdomains dominated by a mixed β-sheet flanked on one side by α-helices and their C-terminal subdomains containing a four stranded anti-parallel β-sheet [, , , ].Aneurinibacillus thermoaerophilus protein has been characterised as a D-glycero-D-manno-heptose 7-phosphate kinase that adds phosphate group to C-1 of D-glycero-D-manno-heptose 7-phosphate [ ], and has been called GmhB or HddA. Note that HddA is the preferred name for this protein because the name GmhB has also been used for the D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase, [ , ]. This enzyme catalyses a step in the biosynthesis of the nucleotide-activated form GDP-D-glycero-D-manno-heptose [] and is encoded by the heptose operon [].D-glycero-D-manno-heptose is a constituent of lipopolysaccharide (LPS) cores of Gram-negative bacteria, and also a component of the S-layer glycoprotein of the Gram-positive bacterium Aneurinibacillus thermoaerophilus. The principal architecture of S-layer glycoproteins resembles that of the LPS of Gram-negative bacteria and comparable pathways are used for the biosynthesis of these similar glycoconjugates [ ].WcbL of Burkholderia pseudomallei is also involved in the synthesis of an LPS (type I O-polysaccharide moieties) [ ].LmbP is thought to belong to the lincomycin-production gene cluster of Streptomyces lincolnensis [ ].
Short Name	Heptose_7-P_kinase