Protein Domain : Adenovirus large t-antigen, E1B 55kDa protein IPR002612

Type	Family
Description	This family consists of adenovirus E1B 55kDa protein or large t-antigen. E1B 55kDa binds p53 the tumor suppressor protein converting it from a transcriptional activator which responds to damaged DNA in to an unregulated repressor of genes with a p53 binding site [ ]. This protects the virus against p53 induced host antiviral responses and prevents apoptosis as induced by the adenovirus E1A protein [].The E1B region of adenovirus encodes two proteins E1B 55kDa, the large t-antigen as found in this family and E1B 19kDa , the small t-antigen. Both of these proteins inhibit E1A induced apoptosis.
Short Name	Adeno_E1B_55kDa