Protein Domain : Protein of unknown function UCP005295 IPR012022

Type	Family
Description	Members of this group are predicted to be metal-dependent hydrolases based on sequence analysis. They are related to Mg-dependent DNases and contain a TadD DNase domain. However, the similarity is not strong enough to confidently predict that these proteins are necessarily DNases and not some other type of metal-dependent hydrolase. Another related group is the TatD deoxyribonuclease family.Members of this group may be distantly related to a large 3D fold-based domain superfamily of metalloenzymes [ ]. The description of this fold superfamily was based on an analysis of conservation patterns in three dimensions, and the discovery that the same active-site architecture occurs in a large set of enzymes involved primarily in nucleotide metabolism. The group is thought to include urease, dihydroorotase, allantoinase, hydantoinase, AMP-, adenine- and cytosine- deaminases, imidazolonepropionase, aryldialkylphosphatase, chlorohydrolase, formylmethanofuran dehydrogenase, and other enzymes [].
Short Name	UCP005295