Protein Domain : Proline/serine-rich coiled-coil protein 1/G2 and S phase-expressed protein 1 IPR026657

Type  Family
Description  This is a family of phosphoproteins which includes proline/serine-rich coiled-coil protein 1 (PSRC1, also known as DDA3) and G2 and S phase-expressed protein 1 (GTSE1).DDA3 is a microtubule-destabilising protein that controls spindle dynamics and mitotic progression by regulating microtubule depolymerases, such as Kif2a and MCAK [ , ]. Deletion of DDA3 causes spindle hyper-stabilisation, inter-kinectochore tension loss, chromosome congression defects. This leads to unaligned chromosomes at metaphase and the accumulation of CENP-E (a plus end-motor protein) at kinectochore in these chromosomes []. It has also been suggested that DDA3 may participate in p53/TP53-regulated growth suppression []. GTSE1 may be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis [ ]. When overexpressed, GTSE1 delays G2/M phase progression [].
Short Name  DDA3/GTSE-1
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