Protein Domain : Bride of sevenless protein IPR002956

Type	Family
Description	During development of the Drosophila retina, the bride of sevenless (boss) gene is required in photoreceptor neuron R8 for the development ofphotoreceptor neuron R7, suggesting that boss encodes or regulates an R7-specific inductive cue []. The induction of R8 photoreceptor neuronneighbouring cells to assume an R7 cell fate is believed to be mediated by a direct interaction of boss with sevenless [, ]. An alternative model hasbeen proposed in which the boss protein functions as a receptor, based on a (superficial) similarity to the G-protein-coupled family of membrane receptors [ ]. The boss gene encodes a protein of 896 amino acids with a putative N-terminal signal sequence, a large N-terminal extra-cellular domain, seventransmembrane (TM) segments and a C-terminal cytoplasmic tail [ , ]. Theboss protein from Drosophila virilis (Fruit fly) shares a high level of amino acid identity with the Drosophila melanogaster (Fruit fly) homologue, with highest levels ofsimilarity in the TM domains [ ].
Short Name	Bride_of_7less