Protein Domain : Microtubule associated protein MAP2/MAP4/Tau IPR027324

Type	Family
Description	Proteins in this family contains a microtubule binding domain that is found in MAP2, MAP4, Tau, and their homologues. All isoforms contain a conserved C-terminal domain containing tubulin-binding repeats ( ), and a N-terminal projection domain of varying size. This domain has a net negative charge and exerts a long-range repulsive force. This provides a mechanism that can regulate microtubule spacing which might facilitate efficient organelle transport [, ].MAP2 may stabilise the microtubules against depolymerisation [ , ]. MAP4 is a non-neuronal microtubule-associated protein that promotes microtubule assembly [ , ]. Tau promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity [ ]. Hyperphosphorylated forms of TAU has been linked to Alzheimer disease [].
Short Name	MAP2/MAP4/Tau