Protein Domain : KASH domain IPR012315

Type	Domain
Description	The KASH (Klarsicht/ANC-1/Syne-1 homology), or KLS domain is a highly hydrophobic nuclear envelope localization domain of approximately 60 amino acids comprising a 20-amino-acid transmembrane region and a 30-35-residue C-terminal region that lies between the inner and the outer nuclear membranes. The KASH domain is found in association with other domains, such as spectrin repeats and CH, at the C terminus of proteins tethered to the nuclear membrane in diverse cell types [ , , , , ].Some proteins known to contain a KASH domain are listed below:Caenorhabditis elegans nuclear anchorage protein 1 (ANC-1).Drosophila Klarsicht (Klar), a protein associated with nuclei and required for a subset of nuclear migrations.Drosophila MSP-300.Vertebrate nesprin-1, -2, -3 and -4 (also known as Syne1-4). They are components of the linker of the nucleoskeleton and cytoskeleton (LINC) complex, which plays critical roles in nuclear positioning, cell polarisation and cellular stiffness [].
Short Name	KASH