Protein Domain : DNA mismatch repair protein MutL/Mlh/Pms IPR038973

Type  Family
Description  Mismatch repair contributes to the overall fidelity of DNA replication by targeting mispaired bases that arise through replication errors during homologous recombination and as a result of DNA damage. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex [ ]. This entry represents a family of evolutionarily related DNA mismatch repair proteins, including MutL, Mlh1, Mlh2 and Mlh3, and Pms 1 and 2. Bacterial MutL proteins are homodimers, while their eukaryotic homologues form heterodimers consisting of the MutL homologue Mlh1 and either Pms1, Pms2 or Mlh3 [, ]. MutL homologues share a conserved ATP binding site [].
Short Name  MutL/Mlh/Pms

1 Child Features

0 Gene Families

0 Genes

4 Ontology Annotations

0 Parent Features

0 Publications

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