Protein Domain : Small drug/metabolite transporter protein family IPR000390

Type	Family
Description	Members of this family which have been characterised, belong to the small multidrug/metabolite transporter family and are integral membrane proteins. They confer resistance to a wide range of toxic compounds by removing them for the cells. The efflux is coupled to an influx of protons. It includes 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE and ArnF, which are components of the undecaprenyl-phosphate-alpha-L-Ara4N flippase that translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol from the cytoplasmic to the periplasmic side of the inner membrane during lipopolysaccharide biosynthesis and is involved in polymyxin resistance [ ]. Another example is Escherichia coli EmrE which confers resistance to a wide range of toxic compounds, including ethidium, methyl viologen [ , ], benzalkonium, propidium, dequalinium and different aromatic cation antibiotics and it is also involved in ethidium bromide efflux [, ]. It simultaneously binds and cotransports proton and drug [, ].
Short Name	Small_drug/metabolite_transptr