LIS - Legume Information System
Information about legume traits for crop improvement
CicerMine
v5.1.0.3
Cicer data from the Legume Information System
v5.1.0.3
Cicer data from the Legume Information System
| Type | Domain |
| Description | Receptor-type tyrosine-protein phosphatase mu (R-PTP-mu) belongs to the type 2B subfamily of receptor protein tyrosine phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs catalyze the dephosphorylation of phosphotyrosine peptides [ , , ]. R-PTP-mu is a homophilic cell adhesion molecule expressed in cells which display a cellular network such as neurons and glia in the central nervous system [, ]. It is required for neurite outgrowth []. Loss of this protein contributes to tumor cell migration and dispersal of human glioblastomas [, , , , ]. It contains an extracellular region with an Meprin-A5 (neuropilin)-mu (MAM) domain, an immunoglobulin (Ig) domain, and four fibronectin type III (FN3) repeats, a transmembrane domain, and an intracellular segment with a juxtamembrane domain similar to the cytoplasmic domain of classical cadherins and two tandem PTP domains [, ]. This entry represents the first catalytic PTP domain (repeat 1) found in the protein R-PTP-mu found in chordates. |
| Short Name | R-PTP-mu_cat_rpt1 |
