Protein Domain : RWD domain-containing protein 3 IPR038840

Type  Family
Description  RWDD3, also known as RSUME, is a RWD-containing protein that enhances SUMO conjugation by interacting with the SUMO conjugase Ubc9, increases Ubc9 thioester formation and therefore favours sumoylation of specific targets. It also increases IkappaB levels and stabilizes HIF-1alpha during hypoxia, leading to inhibition of NF-kappaB and increased HIF-1 transcriptional activity [ , ].
Short Name  RWDD3

0 Child Features

0 Gene Families

0 Genes

3 Ontology Annotations

0 Parent Features

0 Publications

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