Protein Domain : Partitioning defective protein 6, PB1 domain IPR034868

Type	Domain
Description	PAR-6 is essential for asymmetric division of the Caenorhabditis elegans zygote and for cell polarization in the Drosophila embryo [ , , ]. Mammalian Par6 binds to Par3 and aPKC, as well as to the small GTPase Cdc42, to form a complex which is a major cell polarity regulator []. This complex has been implicated in the formation of tight junctions (TJ) in mammalian epithelial cells. Whereas only one par-6 gene exists in Drosophila and C. elegans, a family of four is present in mammals, designated as Par6A-D [], although no full-length clone of Par6D has yet been identified. Par6 isoforms A-C localize differently when expressed in MDCK epithelial cells and have distinct effects on TJ formation [].Par6 contains an N-terminal PB1 domain, a C-terminal PDZ domain and a semi-CRIB motif immediately preceding the PDZ domain. The PB1 domain of Par6 forms a hetero-dimer with the PB1 domain of aPKC [ ].
Short Name	PB1_Par6