Protein Domain : Activity-dependent neuroprotector homeobox protein IPR038861

Type	Family
Description	This entry includes a group of homeobox proteins, including ADNP and ADNP2 [ ]. ADNP regulates the expression of >400 genes during embryonic development, vital for mammalian brain formation [ , ]. It has been linked to neurodegenerative diseases and has been shown to play an important roles in autophagy. ADNP has also been associated with the pathophysiology of schizophrenia []. ADNP de novo mutations in humans result in a syndromic form of autism-like spectrum disorder (ASD), including cognitive and motor deficits, the ADNP syndrome (Helsmoortel-Van Der Aa) [].
Short Name	ADNP/ADNP2