Protein Domain : hnRNP A2/B1, RNA recognition motif 1 IPR034486

Type	Domain
Description	This entry represents the RNA recognition motif 1 (RRM1) of hnRNP A2/B1. Heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 is an RNA trafficking response element-binding protein that interacts with the hnRNP A2 response element (A2RE), a cis-acting signal present in certain trafficked mRNAs, including those encoding myelin basic protein (MBP), CaMKII, neurogranin, and Arc [ , , ]. Besides RNA trafficking, hnRNP A2/B1 is also involved in many aspects of mRNA processing, including packaging of nascent transcripts, splicing of pre-mRNAs, and translational regulation [ ]. For instance, it functions as a splicing factor that regulates alternative splicing of tumour suppressors, such as BIN1, WWOX, the antiapoptotic proteins c-FLIP and caspase-9B, the insulin receptor (IR), and the RON proto-oncogene among others []. The overexpression of hnRNP A2/B1 has been linked to many cancers and may play a role in tumor cell differentiation []. hnRNP A2/B1 contains two RNA recognition motifs (RRMs), followed by a long glycine-rich region at the C terminus [].
Short Name	hnRNPA2B1_RRM1