Protein Domain : Nab3, RNA recognition motif IPR034167

Type	Domain
Description	This entry represents the RNA recognition motif (RRM) of Nab3p (also known as Hmd1p), an acidic nuclear polyadenylated RNA-binding protein that is essential for cell viability. Nab3p is predominantly localized within the nucleoplasm and essential for growth in budding yeast [ ]. It plays an important role in the maintenance of CLN3 mRNA levels []. It is part of the Nrd1 complex (Nrd1p-Nab3p-Sen1p) that directs the termination and processing of short RNA polymerase II transcripts and regulates cellular response to nutrient availability []. Nab3p contains an N-terminal aspartic/glutamic acid-rich region, a central RNA recognition motif (RRM), and a C-terminal region rich in glutamine and proline residues [ ].This group of proteins also includes Uncharacterized RNA-binding protein C3H8.09c from Schizosaccharomyces pombe, the ortologous protein in fission yeast.
Short Name	Nab3_RRM