Protein Domain : Autophagy protein Atg19/Atg34, C-terminal IPR024543

Type	Domain
Description	Autophagy is generally known as a process involved in the degradation of bulk cytoplasmic components that are sequestered into double-membrane vesicles to form the autophagosome. The contents of the autophagosome are delivered to the degradative organelle, the lysosome/vacuole, for breakdown and eventual recycling of the resulting macromolecules. In contrast to autophagy, the cytoplasm to vacuole transport (Cvt) pathway is a highly selective process that involves the sequestration of at least two specific cargos that are resident vacuolar hydrolases: aminopeptidase I (Ape1) and alpha-mannosidase (Ams1). These proteins are sequestered within a double-membrane vesicle, termed a Cvt vesicle. The Cvt vesicle is fairly consistent in size, and is much smaller than the autophagosome, being 140-160 nm in diameter.The genes involved in autophagy in yeast are termed autophagy-related (Atg) genes. Autophagy and the Cvt pathway are topologically and mechanistically similar and share most of the Atg components []. The precursor of Ape1 (prApe1) is sequestered within either Cvt vesicles or autophagosomes, depending on the nutrient conditions, and delivered to the vacuole.Atg19 is a peripheral membrane protein with differing binding sites for both Ape1 and Ams1. Atg19 plays a central role in cargo sorting and transport to the vacuole by linking Ams1 and prApe1 to Atg8 and Atg11 [ ].This entry represents the C-terminal region of Atg19 and homologue Atg34 (Yol083wp) [ , ]. The Atg8-binding region is thought to be in the very C-terminal residues [].
Short Name	Atg19/Atg34_C