Protein Domain : ABC-2 transporter IPR000412

Type	Family
Description	ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily which uses the hydrolysis of ATP to energise diverse biological import and exportsystems. ABC transporters are minimally constituted of two conserved regions: a highly conserved ATP binding cassette (ABC) and a lessconserved transmembrane domain (TMD). These regions can be found on the same protein (mostly in eukaryotes and bacterial exporters) or on two differentones (mostly bacterial importers) [ ]. But in a subgroup of exporters, thetransmembrane region is encoded by a separated polypeptide, the ABC-2 type transport system integral membrane protein. The molecular size of thistransmembrane protein is around 30kDa. It is thought to contain six transmembrane regions, it either form homooligomeric channels or associatewith another type of transmembrane protein to form heteroligomers. The function of the integral inner-membrane protein is to translocate thesubstrate across the membrane and seems to play an important role in substrate recognition [].
Short Name	ABC_2_transport